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Myeloproliferative Neoplasms: Biology and Therapy, 1st ed. 2011
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Myeloproliferative Neoplasms Biology and Therapy, 2011
(Contemporary Hematology)
Srdan Verstovsek and Ayalew Tefferi
ISBN-10: 1607612658
ISBN-13: 978-1607612650
Humana Press




This succinct resource provides an ideal balance of the biology and practical therapeutic strategies for classic and non-classic BCR-ABL-negative myeloproliferative neoplasms. Utilizing current World Health Organization nomenclature, classification, and diagnostic criteria, international experts have assembled to convey the most up-to-date knowledge in this rapidly evolving field. The opening chapters cover the diagnosis and classification, genetics, cytogenetic findings, and prognostic factors of MPNs. Further chapters explore therapies specific to the different disease entities, including polycythemia vera, essential thrombocytopenia, myelofibrosis, and eosinophilic disorders, and mastocytosis. Unique areas of discussion include JAK2 inhibitor therapy, hematopoietic stem cell transplantation, and blastic transformation. A valuable reference for practicing hematologists, this forefront book enriches our understanding of recent discoveries and their impact on conventional and investigational treatments.




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Viagra: A Brand That Won't Go Away (by Molly Sunderdick)
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Viagra: A Brand That Won't Go Away (by Molly Sunderdick)

Remember That Brand? Well It’s Back! One would have to travel to the back woods of the Appalachians or perhaps to the cave dwellings in the Southwestern canyons to find anyone who has not heard of cheap viagra. Viagra, the market-leader of male erectile dysfunction prescription drugs, continues to occupy valuable space in the mind of the male consumer. What is so enchanting about an erectile dysfunction pill? How does Viagra have such appeal when it is the focus of late night comedy and radio morning shows? As consumers we seldom question a successful product. (Or maybe we just would rather not have to address or explain male erectile disorder more than we have to).

The consumer is exposed to a pill with a split personality. Viagra lives a double life:
one of in-your-face comedy and one of universal solution. Despite the advertising
that continually tests our comfort elasticity, Viagra’s brand works harder than any
other “miracle drug” to be accepted by the tempestuously self-conscious male
population. Viagra’s branding adheres and accommodates to the male population as
a whole, not only to males with sexual difficulties. Viagra evaluates precepts
regarding acceptance and community before considering the shock thresholds of
consumers in general.

No one was prepared for the introduction of male erectile dysfunction pills into the
mass market. No one anticipated the chain-reaction commercials of multiple
brands, all of which utilizing paradoxical humor to attract attention. Even
consumers desensitized to long lists of side-effects had to turn their heads at the
possibility of a “four hour erection.” That kind of threat stops the music and eye
contact among the group of people in the room is avoided like the plague until the
“funny guy” severs the tension by making a crass comment about a baseball bat.
The Viagra brand applauds him.

Viagra, the pioneer pill for erectile dysfunction, assumed an initially subtle
brandface of advice, information, and medical concern. This initial brand messaging
tossed Viagra into the big black cauldron with Claritin, Lipitor, and other drugs. The
brand was not reaching out to the male population effectively and subsequently had
to consider how men think, feel, and most importantly, what they believe to be true.

What do advertising agencies and mass media companies do best? Raise the stakes
and provide entertainment, which are characteristically male standards. Viagra had
to exude coolness. Viagra had to force the brand into the public eye, and the best
solution was laughter. Consequently, Viagra’s logo was slapped onto the hood of
Mark Martin’s number six car, spokesman Bob Dole’s stiff posture took on a whole
new meaning, and professional baseball star Rapheal Palmero of the Baltimore
Orioles assured men that it was okay to be batting a little below average. With
slogans like “Remember that guy? Well, he’s back!” Viagra took the market by storm
and made erectile dysfunction look as “hip” as possible. In turn, Viagra became the
laughing stock of the drug market. Afflicted males enthusiastically bought into the
brand, embarrassed as ever.

Cialis, Levitra, and a few others surfaced, invading the market with imitations. cheap cialis
and Levitra soon became the Miller and Coors of male erectile dysfunction,
producing the same, if not more over-the-top messages in order to compete.
Levitra featured Mike Ditka coaching affected men to “stay in the game to come out
champions.” Levitra also launched an attack from the female perspective. During
halftime the consumer would see a highly attractive woman on the screen reveal
how her man can last longer than the Energizer Bunny. Levitra pulled out all the
stops to compete with Viagra, and they were not alone. Cialis, the brand that
suggests, “He will never know when a moment will become the right moment,” took
up arms. After all a man never knows when his soldier will be called to duty.

Viagra is consistently in the consumers considered set for prescription drugs, and
more importantly, Viagra has secured a positive space as “the solution” in the minds
of all men. The male ego does not allow men to admit disability to anyone,
including himself. Viagra’s brand targets precepts of acceptance and community in
a seemingly unorthodox manner, making jokes, providing endless comedic material.
Viagra breaks consumers with its initial shock value and quickly proves to be a
catalyst, lowering the anxiety of men wanting help.

A man is more likely to go into a physician’s office and request a prescription for
Viagra than he is to ask for a solution for his erectile dysfunction. He is also more
likely to ask for Viagra than to seek information for himself on the Internet or in a
magazine. Perhaps Viagra provides security in the way that it labels the solution as
opposed to describing the problem. Men with erectile dysfunction want to feel as
though they are suffering from something ordinary like arthritis. Everyone has it.
Everyone accepts it. Everyone gets help for it. The importance of “everyone,” even if
everyone is laughing at Viagra, is significant enough to raise the consumer
temperature.

Viagra’s commercials drops jaws, and erectile dysfunction is still taboo in our sex-
crazed society, but Viagra will go down in history as one of the most influential
drugs of all time because the brand succeeded in dropping anchor in the mind of
the male consumer. The acceptance of Viagra confirms that the precepts prevail as
miracle drugs for products of even the most self-conscious nature. The consumer
may gaze at the screen contemplating how much money Viagra pays its spokesmen,
but at least he knows that everyone is watching.

Molly Sunderdick
Brand Strategist
Stealing Share, Inc

El Sildenafil induce perdida de la Audicion
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Un nuevo estudio de la Universidad de Alabama en Estados Unidos indica que los hombres que toman cheap cialis tendrían el doble de riesgo de sufrir un deterioro de la audición. El estudio, sobre una muestra de hombres estadounidenses de más de 40 años, reveló que 1 de cada 6 que lo tomaron eran sordos o tenían problemas de audición y 1 de cada 3 tenía pérdida auditiva total. Los fabricantes de esos fármacos ya incluyen una advertencia de la potencial pérdida de la audición. La investigación sugiere que existe una acumulación de cambios en el tiempo. En los hombres sin problemas auditivos y con disfunción eréctil, lo importante es comparar el potencial efecto adverso con el problema real.


Bob Dole found a job after he lost too
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And cheap cialis works fast. In fact, cialis works in as quickly as 30 minutes. Then, you have at least 4 hours to have a romantic experience at your own pace. In most patients, VIAGRA can be taken once a day as needed.

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